KMID : 0378019870300030085
|
|
New Medical Journal 1987 Volume.30 No. 3 p.85 ~ p.90
|
|
A Clinical Effect of Aclatonium Napadisilate (Aclaton^(¢ç)) in Patient with Functional Dyspepsia
|
|
|
|
Abstract
|
|
|
The clinical effectiveness of Aclatonium napadisilate was evaluated in 63 patients with functional dys -psia (nonulcer dyspepsia and irritable bowel syndrome) which were diagnosed with through history, physical examination, upper gastrointestinal x-ray examination, gastrofiberscopy and ultrasono- m in Kangnam St. Mary¢¥s Hospital, Catholic Medical Center. In this open clinical trial at the out-patient clinic, 25mg-50mg of Aclatonium napadisilate was given orally 30 minutes before meal 3 times a day for -6 wks. The effectiveness was assessed by the subjective decision about every subjective symptoms in 4 different degrees; excellent, good, fair and no effective, and the cases with excellent or good respon.es to the drug were scored as effective.
The results were summerized as follows:
1. The clinical symptoms of the patients with functional dyspepsia were epigastric discomford and or indigestion 92%, abdominal fullness 81%, nausea 66.7%, anorexia, sore 60.3%, loose stool 23.4%, constipation 17.5% as in orders.
2. The mean clinical improvement rates after Aclatonium napdisilate treatment were different in du ation, 52.5% in 2 wks, 71.3% in 4 wks and 80.5% in 6 wks treatment.
3. Good & excellent improvement was obtaned in 75.0% of 63 patients after 6 wks treatment. Especia ly, epigastric discomfort, abdominal fullness, nauseas were most significantly improved with of -ctiveness were up to 85%.
4. There were no significant untoward side reactions except transient bowel habit change which were not severe enough to discontinue the medications.
In conclusion, Aclatonium napadisilate considered as a new efficient musculotropic agents in the treatment of various functional & motility disorders of the gastrointestinal tracts.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|